InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Txn2

Summary

InnateDB Gene

IDBG-158473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txn2

Gene Name

thioredoxin 2

Synonyms

2510006J11Rik; AI788873; Trx2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005354

Encoded Proteins

IDBP-158475

thioredoxin 2

IDBP-158477

thioredoxin 2

IDBP-261725

thioredoxin 2

IDBP-261727

thioredoxin 2

IDBP-627187

thioredoxin 2

IDBP-627190

thioredoxin 2

IDBP-627193

thioredoxin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100348:
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:77915047-77929006

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005487	ENSMUSP00000005487
ENSMUST00000100486	ENSMUSP00000098055
ENSMUST00000109748	ENSMUSP00000105370
ENSMUST00000109747	ENSMUSP00000105369
ENSMUST00000173561
ENSMUST00000173631	ENSMUSP00000134682
ENSMUST00000174468	ENSMUSP00000133548
ENSMUST00000174529	ENSMUSP00000133605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008113	peptide-methionine (S)-S-oxide reductase activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0032403	protein complex binding
GO:0033743	peptide-methionine (R)-S-oxide reductase activity

Biological Process

GO:0001666	response to hypoxia
GO:0006662	glycerol ether metabolic process
GO:0006979	response to oxidative stress
GO:0007584	response to nutrient
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0014070	response to organic cyclic compound
GO:0031669	cellular response to nutrient levels
GO:0042493	response to drug
GO:0045454	cell redox homeostasis
GO:0048678	response to axon injury
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0030425	dendrite
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000100348

View Gene Order

ENSBTAG00000000014

Not yet available

Pathways

NETPATH

REACTOME

REACT_188957

Cellular responses to stress pathway

REACT_189141

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_120956

Cellular responses to stress pathway

REACT_172715

Detoxification of Reactive Oxygen Species pathway

REACT_206069

Cellular responses to stress pathway

REACT_204534

Detoxification of Reactive Oxygen Species pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.291917 Mm.486493

RefSeq

NM_019913

OMIM

CCDS

CCDS27606

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas