Version 5.4
Homo sapiens Gene: TXN2
Summary
InnateDB Gene IDBG-5938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXN2
Gene Name thioredoxin 2
Synonyms MT-TRX; MTRX; TRX2
Species Homo sapiens
Ensembl Gene ENSG00000100348
Encoded Proteins
IDBP-5940
thioredoxin 2
IDBP-294030
thioredoxin 2
IDBP-719823
IDBP-374735
thioredoxin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:36467036-36482030
Strand Reverse strand
Band q12.3
Transcripts
ENST00000216185 ENSP00000216185
ENST00000403313 ENSP00000385393
ENST00000416967 ENSP00000469160
ENST00000411915 ENSP00000409407
ENST00000487725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008113 peptide-methionine (S)-S-oxide reductase activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0032403 protein complex binding
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
Biological Process
GO:0001666 response to hypoxia
GO:0006662 glycerol ether metabolic process
GO:0006979 response to oxidative stress
GO:0007584 response to nutrient
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0014070 response to organic cyclic compound
GO:0031669 cellular response to nutrient levels
GO:0042493 response to drug
GO:0045454 cell redox homeostasis
GO:0048678 response to axon injury
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005354
View Gene Order
ENSBTAG00000000014
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q99757
TrEMBL B4DX69 F8WDN2 M0QXH0
UniProt Splice Variant
Entrez Gene 25828
UniGene
RefSeq NM_012473 XM_005261508
HUGO HGNC:17772
OMIM 609063
CCDS CCDS13928
HPRD
IMGT
EMBL AF276920 AF480262 AK301837 AL022313 BC013726 BC050610 CH471095 CR456601 CR541896 CR541917 U78678
GenPept AAB41631 AAF86467 AAH13726 AAH50610 AAN05576 BAG63281 CAG30487 CAG46694 CAG46715 CAQ06700 EAW60103
RNA Seq Atlas 25828

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca