Version 5.4
Mus musculus Gene: March1
Summary
InnateDB Gene IDBG-158596.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March1
Gene Name membrane-associated ring finger (C3HC4) 1
Synonyms 2900024D24Rik; BB085186
Species Mus musculus
Ensembl Gene ENSMUSG00000036469
Encoded Proteins
IDBP-158598
membrane-associated ring finger (C3HC4) 1
IDBP-158600
membrane-associated ring finger (C3HC4) 1
IDBP-158602
membrane-associated ring finger (C3HC4) 1
IDBP-260655
membrane-associated ring finger (C3HC4) 1
IDBP-260657
membrane-associated ring finger (C3HC4) 1
IDBP-260659
membrane-associated ring finger (C3HC4) 1
IDBP-260661
membrane-associated ring finger (C3HC4) 1
IDBP-260663
membrane-associated ring finger (C3HC4) 1
IDBP-716658
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145416:
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:65617900-66471637
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000098708 ENSMUSP00000096305
ENSMUST00000072482 ENSMUSP00000072302
ENSMUST00000039540 ENSMUSP00000044070
ENSMUST00000110259 ENSMUSP00000105888
ENSMUST00000110258 ENSMUSP00000105887
ENSMUST00000110256 ENSMUSP00000105885
ENSMUST00000110255 ENSMUSP00000105884
ENSMUST00000110253 ENSMUSP00000105882
ENSMUST00000152320
ENSMUST00000155804
ENSMUST00000178982 ENSMUSP00000136545
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042287 MHC protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0006955 immune response
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145416
View Gene Order
ENSBTAG00000044082
Not yet available
Cross-References
SwissProt Q6NZQ8
TrEMBL
UniProt Splice Variant
Entrez Gene 72925
UniGene Mm.380457 Mm.418654
RefSeq NM_001166372 NM_001166375 NM_175188 XM_006509754 XM_006509756 XM_006509757 XM_006509758 XM_006509759
OMIM
CCDS CCDS52560 CCDS22333 CCDS52561
HPRD
IMGT
MGI ID MGI:1920175
MGI Symbol March1
EMBL AK036489 AK089040 AK137337 AK152592 AK163081 BC066008
GenPept AAH66008 BAC29449 BAC40715 BAE23311 BAE31341 BAE37183
RNA Seq Atlas 72925

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca