Version 5.4
Mus musculus Protein: March1
Summary
InnateDB Protein IDBP-260663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol March1
Protein Name membrane-associated ring finger (C3HC4) 1
Synonyms 2900024D24Rik; BB085186;
Species Mus musculus
Ensembl Protein ENSMUSP00000105882
InnateDB Gene IDBG-158596 (March1)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. {ECO:0000269PubMed:17051151, ECO:0000269PubMed:17255932, ECO:0000269PubMed:19880452, ECO:0000269PubMed:19917682}.
Subcellular Localization Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000269PubMed:19880452}. Early endosome membrane {ECO:0000269PubMed:19880452}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:19880452}. Lysosome membrane {ECO:0000269PubMed:19880452}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042287 MHC protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0006955 immune response
Cellular Component
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
Protein Structure and Domains
PDB ID MGI:1920175
InterPro IPR001841 Zinc finger, RING-type
IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF12906
PF00097
PRINTS
PIRSF
SMART SM00184
SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NZQ8
PhosphoSite PhosphoSite-Q6NZQ8
TrEMBL
UniProt Splice Variant
Entrez Gene 72925
UniGene Mm.418654
RefSeq
MGI ID
MGI Symbol March1
OMIM
CCDS
HPRD
IMGT
EMBL AK036489 AK089040 AK137337 AK152592 AK163081 BC066008
GenPept AAH66008 BAC29449 BAC40715 BAE23311 BAE31341 BAE37183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca