InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ube4a

Summary

InnateDB Gene

IDBG-158750.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube4a

Gene Name

ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059890

Encoded Proteins

IDBP-401212

ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)

IDBP-401211

ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)

IDBP-542117

ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)

IDBP-541168

ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)

IDBP-532830

ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110344:
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn\'s disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:44923131-44965600

Strand

Reverse strand

Band

A5.2

Transcripts

ENSMUST00000117506	ENSMUSP00000113346
ENSMUST00000117549	ENSMUSP00000112632
ENSMUST00000154287	ENSMUSP00000123668
ENSMUST00000145657	ENSMUSP00000115311
ENSMUST00000138559
ENSMUST00000125642	ENSMUSP00000118951
ENSMUST00000155400

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0034450	ubiquitin-ubiquitin ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000110344

View Gene Order

ENSBTAG00000019725

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.215069 Mm.398621 Mm.408858 Mm.409516

RefSeq

NM_145400 XM_006510004

OMIM

CCDS

CCDS23122

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas