InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE4A

Summary

InnateDB Gene

IDBG-73670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE4A

Gene Name

ubiquitination factor E4A

Synonyms

E4; UBOX2; UFD2

Species

Homo sapiens

Ensembl Gene

ENSG00000110344

Encoded Proteins

IDBP-73672

ubiquitination factor E4A

IDBP-383672

ubiquitination factor E4A

IDBP-596545

ubiquitination factor E4A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn\'s disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118359585-118399211

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000252108	ENSP00000252108
ENST00000431736	ENSP00000387362
ENST00000545354	ENSP00000438918

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0034450	ubiquitin-ubiquitin ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000059890

View Gene Order

ENSBTAG00000019725

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.602967 Hs.75275

RefSeq

NM_001204077 NM_004788

HUGO

OMIM

CCDS

CCDS55790 CCDS8396

HPRD

06793

IMGT

EMBL

GenPept

RNA Seq Atlas