Homo sapiens Gene: GSR
Summary
InnateDB Gene IDBG-15878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSR
Gene Name glutathione reductase
Synonyms HEL-75;
Species Homo sapiens
Ensembl Gene ENSG00000104687
Encoded Proteins
glutathione reductase
glutathione reductase
glutathione reductase
glutathione reductase
glutathione reductase
glutathione reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:30678061-30727926
Strand Reverse strand
Band p12
Transcripts
ENST00000221130 ENSP00000221130
ENST00000523295 ENSP00000431044
ENST00000521479 ENSP00000430825
ENST00000546342 ENSP00000445516
ENST00000541648 ENSP00000444559
ENST00000537535 ENSP00000438845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004362 glutathione-disulfide reductase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044281 small molecule metabolic process
GO:0045454 cell redox homeostasis
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glutathione metabolism pathway
INOH
Glutamate Glutamine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P00390
TrEMBL E5RI06
UniProt Splice Variant
Entrez Gene 2936
UniGene Hs.271510
RefSeq NM_001195104 NM_000637 NM_001195102 NM_001195103
HUGO HGNC:4623
OMIM 138300
CCDS CCDS56530 CCDS34877 CCDS56531 CCDS56532
HPRD 00704
IMGT
EMBL AB519179 AB519180 AB519181 AC009314 AC103959 AF215848 AF228703 AF228704 AY338490 BC069244 CH471080 X15722
GenPept AAF37572 AAF37573 AAF37574 AAH69244 AAP88037 BAI43437 BAI43438 BAI43439 CAA33744 EAW63443 EAW63445
RNA Seq Atlas 2936