Version 5.4
Homo sapiens Gene: GSR
Summary
InnateDB Gene IDBG-15878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSR
Gene Name glutathione reductase
Synonyms HEL-75
Species Homo sapiens
Ensembl Gene ENSG00000104687
Encoded Proteins
IDBP-15880
glutathione reductase
IDBP-476528
glutathione reductase
IDBP-476640
glutathione reductase
IDBP-589988
glutathione reductase
IDBP-583471
glutathione reductase
IDBP-590966
glutathione reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:30678061-30727926
Strand Reverse strand
Band p12
Transcripts
ENST00000221130 ENSP00000221130
ENST00000523295 ENSP00000431044
ENST00000521479 ENSP00000430825
ENST00000546342 ENSP00000445516
ENST00000541648 ENSP00000444559
ENST00000537535 ENSP00000438845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004362 glutathione-disulfide reductase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0044281 small molecule metabolic process
GO:0045454 cell redox homeostasis
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031584
View Gene Order
ENSBTAG00000007115
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00480
Glutathione metabolism pathway
INOH
INOH website
Glutamate Glutamine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.271510
RefSeq NM_000637 NM_001195102 NM_001195103 NM_001195104
HUGO
OMIM
CCDS CCDS34877 CCDS56530 CCDS56531 CCDS56532
HPRD 00704
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca