InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GSR

Summary

InnateDB Protein

IDBP-583471.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GSR

Protein Name

glutathione reductase

Synonyms

HEL-75;

Species

Homo sapiens

Ensembl Protein

ENSP00000444559

InnateDB Gene

IDBG-15878 (GSR)

Protein Structure

UniProt Annotation

Function

Maintains high levels of reduced glutathione in the cytosol.

Subcellular Localization

Isoform Mitochondrial: Mitochondrion.Isoform Cytoplasmic: Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004362	glutathione-disulfide reductase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0045454	cell redox homeostasis
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005759	mitochondrial matrix
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR000815 Mercuric reductase
IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF02852
PF07992

PRINTS

PR00469
PR00945
PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00390