Mus musculus Gene: Stc2
InnateDB Gene IDBG-159217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stc2
Gene Name stanniocalcin 2
Synonyms AW125853; mustc2; Stc2l;
Species Mus musculus
Ensembl Gene ENSMUSG00000020303
Encoded Proteins
stanniocalcin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113739:
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:31357307-31370074
Strand Reverse strand
Band A4
ENSMUST00000020546 ENSMUSP00000020546
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006979 response to oxidative stress
GO:0007566 embryo implantation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0033280 response to vitamin D
GO:0034976 response to endoplasmic reticulum stress
GO:0040015 negative regulation of multicellular organism growth
GO:0043434 response to peptide hormone
GO:0046697 decidualization
GO:0055074 calcium ion homeostasis
GO:0071456 cellular response to hypoxia
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Homo sapiens
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
SwissProt O88452
UniProt Splice Variant
Entrez Gene 20856
UniGene Mm.32506 Mm.442854 Mm.442921
RefSeq NM_011491
MGI ID MGI:1316731
MGI Symbol Stc2
EMBL AF031035 AF056244 AK010318 BC012206 CH466604
GenPept AAC27507 AAD01921 AAH12206 BAB26849 EDL23779
RNA Seq Atlas 20856