Homo sapiens Gene: STC2
Summary
InnateDB Gene IDBG-58122.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STC2
Gene Name stanniocalcin 2
Synonyms STC-2; STCRP;
Species Homo sapiens
Ensembl Gene ENSG00000113739
Encoded Proteins
stanniocalcin 2
stanniocalcin 2
stanniocalcin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:173314713-173329503
Strand Reverse strand
Band q35.2
Transcripts
ENST00000265087 ENSP00000265087
ENST00000520593
ENST00000520648 ENSP00000428470
ENST00000518455 ENSP00000427816
ENST00000519511
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 12 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0006874 cellular calcium ion homeostasis
GO:0006979 response to oxidative stress
GO:0007166 cell surface receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007566 embryo implantation
GO:0007584 response to nutrient
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0033280 response to vitamin D
GO:0034976 response to endoplasmic reticulum stress
GO:0040015 negative regulation of multicellular organism growth
GO:0043434 response to peptide hormone
GO:0046697 decidualization
GO:0055074 calcium ion homeostasis
GO:0071456 cellular response to hypoxia
GO:2001256 regulation of store-operated calcium entry
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL E5RG57
UniProt Splice Variant
Entrez Gene 8614
UniGene Hs.233160 Hs.594292
RefSeq NM_003714
HUGO HGNC:11374
OMIM 603665
CCDS CCDS4388
HPRD 04717
IMGT
EMBL AC106731
GenPept
RNA Seq Atlas 8614