Version 5.4
Homo sapiens Gene: DPH1
Summary
InnateDB Gene IDBG-15935.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPH1
Gene Name DPH1 homolog (S. cerevisiae)
Synonyms DPH2L; DPH2L1; OVCA1
Species Homo sapiens
Ensembl Gene ENSG00000108963
Encoded Proteins
IDBP-15937
DPH1 homolog (S. cerevisiae)
IDBP-763437
IDBP-764666
IDBP-763496
IDBP-808426
diphthamide biosynthesis 1
IDBP-761458
IDBP-761751
IDBP-808425
diphthamide biosynthesis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:2030110-2043430
Strand Forward strand
Band p13.3
Transcripts
ENST00000263083 ENSP00000263083
ENST00000571710 ENSP00000460813
ENST00000576891
ENST00000570867
ENST00000575667 ENSP00000460431
ENST00000570477 ENSP00000458726
ENST00000576129
ENST00000575998
ENST00000575162 ENSP00000476598
ENST00000570833 ENSP00000467936
ENST00000572214
ENST00000572819
ENST00000572684
ENST00000572248
ENST00000571418 ENSP00000458838
ENST00000607788 ENSP00000476070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0008283 cell proliferation
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078789
View Gene Order
ENSBTAG00000009376
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513856 Hs.664161
RefSeq NM_001383
HUGO
OMIM
CCDS CCDS42228
HPRD 04634
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca