Mus musculus Gene: Pola1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-159523.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Pola1 | ||||||||||||||||||||||||||
Gene Name | polymerase (DNA directed), alpha 1 | ||||||||||||||||||||||||||
Synonyms | AW321876; Pola | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000006678 | ||||||||||||||||||||||||||
Encoded Proteins |
polymerase (DNA directed), alpha 1
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101868:
This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome X:93304767-93632155 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | C3 | ||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Processive synthesis on the lagging strand pathway
Removal of the Flap Intermediate pathway
Cell Cycle, Mitotic pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Telomere C-strand synthesis initiation pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
DNA Replication pathway
Telomere Maintenance pathway
Cell Cycle pathway
Activation of the pre-replicative complex pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
M/G1 Transition pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Extension of Telomeres pathway
DNA replication initiation pathway
G1/S-Specific Transcription pathway
Polymerase switching pathway
E2F mediated regulation of DNA replication pathway
Lagging Strand Synthesis pathway
DNA Replication Pre-Initiation pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
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KEGG |
Pyrimidine metabolism pathway
DNA replication pathway
Purine metabolism pathway
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INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand synthesis initiation pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
DNA replication initiation pathway
Removal of the Flap Intermediate pathway
Processive synthesis on the lagging strand pathway
Polymerase switching pathway
Leading Strand Synthesis pathway
Activation of the pre-replicative complex pathway
G1/S-Specific Transcription pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Chromosome Maintenance pathway
DNA Replication Pre-Initiation pathway
Telomere Maintenance pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
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KEGG |
Pyrimidine metabolism pathway
DNA replication pathway
Purine metabolism pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
E2F transcription factor network
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Mm.1923 | ||||||||||||||||||||||||||
RefSeq | NM_008892 XM_006527905 XM_006527906 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS30272 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||