Homo sapiens Gene: POLA1
Summary
InnateDB Gene IDBG-53117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLA1
Gene Name polymerase (DNA directed), alpha 1, catalytic subunit
Synonyms NSX; p180; POLA;
Species Homo sapiens
Ensembl Gene ENSG00000101868
Encoded Proteins
polymerase (DNA directed), alpha 1, catalytic subunit
polymerase (DNA directed), alpha 1, catalytic subunit
polymerase (DNA directed), alpha 1, catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:24693919-24996986
Strand Forward strand
Band p22.11
Transcripts
ENST00000379068 ENSP00000368358
ENST00000379059 ENSP00000368349
ENST00000493342
ENST00000480125
ENST00000494204
ENST00000611764 ENSP00000478401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 48 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0003896 DNA primase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000084 mitotic S phase
GO:0000278 mitotic cell cycle
GO:0000722 telomere maintenance via recombination
GO:0000723 telomere maintenance
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006269 DNA replication, synthesis of RNA primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006273 lagging strand elongation
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0008283 cell proliferation
GO:0016032 viral process
GO:0019985 translesion synthesis
GO:0032201 telomere maintenance via semi-conservative replication
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
DNA replication initiation pathway
Synthesis of DNA pathway
Telomere C-strand synthesis initiation pathway
Removal of the Flap Intermediate pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
DNA Replication Pre-Initiation pathway
Telomere Maintenance pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
G1/S-Specific Transcription pathway
Cell Cycle pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Processive synthesis on the lagging strand pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
KEGG
Purine metabolism pathway
Pyrimidine metabolism pathway
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567319
RefSeq NM_016937 XM_005274552 XM_006724499
HUGO
OMIM
CCDS CCDS14214
HPRD 02416
IMGT
EMBL
GenPept
RNA Seq Atlas