Mus musculus Gene: Egln2
Summary
InnateDB Gene IDBG-159886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Egln2
Gene Name EGL nine homolog 2 (C. elegans)
Synonyms 0610011A13Rik; C85656; Hif-p4h-1; Ier4; Phd1; SM-20;
Species Mus musculus
Ensembl Gene ENSMUSG00000058709
Encoded Proteins
EGL nine homolog 2 (C. elegans)
EGL nine homolog 2 (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171570:
RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27158658-27166802
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000080058 ENSMUSP00000078966
ENSMUST00000108382 ENSMUSP00000104019
ENSMUST00000152021
ENSMUST00000134906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826 oxygen sensor activity
GO:0031418 L-ascorbic acid binding
GO:0031543 peptidyl-proline dioxygenase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
Biological Process
GO:0001666 response to hypoxia
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0043523 regulation of neuron apoptotic process
GO:0045454 cell redox homeostasis
GO:0045732 positive regulation of protein catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Cellular response to hypoxia pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
KEGG
Pathways in cancer pathway
Renal cell carcinoma pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q91YE2
TrEMBL Q80X29
UniProt Splice Variant
Entrez Gene 112406
UniGene Mm.29978
RefSeq NM_053208 XM_006539474
OMIM
CCDS CCDS21011
HPRD
IMGT
MGI ID MGI:1932287
MGI Symbol Egln2
EMBL AF340231 AF453879 AJ310547 AK075582 AK152223 BC023299 BC051436 BC086764 CH466593
GenPept AAH23299 AAH51436 AAH86764 AAK37525 AAL65166 BAC35835 BAE31050 CAC42516 EDL24202 EDL24203
RNA Seq Atlas 112406