InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Egln2

Summary

InnateDB Gene

IDBG-159886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Egln2

Gene Name

EGL nine homolog 2 (C. elegans)

Synonyms

0610011A13Rik; C85656; Hif-p4h-1; Ier4; Phd1; SM-20

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058709

Encoded Proteins

IDBP-159888

EGL nine homolog 2 (C. elegans)

IDBP-264658

EGL nine homolog 2 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171570:
RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:27158658-27166802

Strand

Reverse strand

Band

Transcripts

ENSMUST00000080058	ENSMUSP00000078966
ENSMUST00000108382	ENSMUSP00000104019
ENSMUST00000152021
ENSMUST00000134906

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826	oxygen sensor activity
GO:0031418	L-ascorbic acid binding
GO:0031543	peptidyl-proline dioxygenase activity
GO:0031545	peptidyl-proline 4-dioxygenase activity

Biological Process

GO:0001666	response to hypoxia
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0043523	regulation of neuron apoptotic process
GO:0045454	cell redox homeostasis
GO:0045732	positive regulation of protein catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000171570

View Gene Order

ENSBTAG00000017996

Not yet available

Pathways

NETPATH

REACTOME

REACT_188957

Cellular responses to stress pathway

REACT_199106

Cellular response to hypoxia pathway

REACT_199108

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway

REACT_199109

Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway

KEGG

mmu05211

Renal cell carcinoma pathway

mmu05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

Q91YE2

TrEMBL

Q80X29

UniProt Splice Variant

Entrez Gene

112406

UniGene

Mm.29978

RefSeq

NM_053208 XM_006539474

OMIM

CCDS

CCDS21011

HPRD

IMGT

MGI ID

MGI:1932287

MGI Symbol

Egln2

EMBL

AF340231 AF453879 AJ310547 AK075582 AK152223 BC023299 BC051436 BC086764 CH466593

GenPept

AAH23299 AAH51436 AAH86764 AAK37525 AAL65166 BAC35835 BAE31050 CAC42516 EDL24202 EDL24203

RNA Seq Atlas

112406