Version 5.4
Mus musculus Gene: Lcn2
Summary
InnateDB Gene IDBG-160059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lcn2
Gene Name lipocalin 2
Synonyms 24p3; AW212229; Sip24
Species Mus musculus
Ensembl Gene ENSMUSG00000026822
Encoded Proteins
IDBP-160063
lipocalin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26190773
Macrophage iron regulatory proteins Aco1 and Ireb2 are protective against Salmonella by promoting the induction of Lcn2, a host antimicrobial factor that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.
InnateDB Annotation from Orthologs
Summary
PMID 25398327
[Homo sapiens] LCN2 is secreted by the urinary tract mucosa in response to uropathogenic E. coli challenge and acts in innate immune defences as a colonization barrier.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148346:
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32384633-32387797
Strand Reverse strand
Band B
Transcripts
ENSMUST00000050785 ENSMUSP00000053962
ENSMUST00000147219
ENSMUST00000144569
ENSMUST00000155830
ENSMUST00000136509
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 1 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005215 transporter activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0036094 small molecule binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006811 ion transport
GO:0006979 response to oxidative stress
GO:0009615 response to virus
GO:0009617 response to bacterium
GO:0009635 response to herbicide
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0015891 siderophore transport
GO:0031346 positive regulation of cell projection organization
GO:0031667 response to nutrient levels
GO:0031669 cellular response to nutrient levels
GO:0042493 response to drug
GO:0045087 innate immune response (InnateDB)
GO:0070207 protein homotrimerization
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148346
View Gene Order
ENSBTAG00000014149
Not yet available
Pathways
NETPATH
REACTOME
REACT_268398
Orphan transporters pathway
REACT_205755
Iron uptake and transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25060
Iron uptake and transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_267716
Orphan transporters pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_008491
OMIM
CCDS CCDS15913
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca