Version 5.4
Mus musculus Gene: Rtkn
Summary
InnateDB Gene IDBG-160256.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rtkn
Gene Name rhotekin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034930
Encoded Proteins
IDBP-160258
rhotekin
IDBP-160260
rhotekin
IDBP-401082
rhotekin
IDBP-537828
rhotekin
IDBP-533349
rhotekin
IDBP-535373
rhotekin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114993:
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83135463-83152579
Strand Forward strand
Band C3
Transcripts
ENSMUST00000065512 ENSMUSP00000065571
ENSMUST00000087938 ENSMUSP00000085249
ENSMUST00000121093 ENSMUSP00000112501
ENSMUST00000135490 ENSMUSP00000116964
ENSMUST00000130622 ENSMUSP00000122660
ENSMUST00000129316 ENSMUSP00000120640
ENSMUST00000133226
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017048 Rho GTPase binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007266 Rho protein signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114993
View Gene Order
ENSBTAG00000000490
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8C6B2
TrEMBL D3YXC9 D3Z7S7
UniProt Splice Variant
Entrez Gene 20166
UniGene Mm.4139
RefSeq NM_001136227 NM_009106 NM_133641
OMIM
CCDS CCDS51817 CCDS20274
HPRD
IMGT
MGI ID MGI:107371
MGI Symbol Rtkn
EMBL AC104324 AK076155 BC013820 U54638
GenPept AAC52605 AAH13820 BAC36222
RNA Seq Atlas 20166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca