Version 5.4
Homo sapiens Gene: RTKN
Summary
InnateDB Gene IDBG-57314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTKN
Gene Name rhotekin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114993
Encoded Proteins
IDBP-57316
rhotekin
IDBP-57318
rhotekin
IDBP-57320
rhotekin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:74425836-74442422
Strand Reverse strand
Band p13.1
Transcripts
ENST00000272430 ENSP00000272430
ENST00000305557 ENSP00000305298
ENST00000233330 ENSP00000233330
ENST00000492013
ENST00000469859
ENST00000479256
ENST00000472518
ENST00000464094
ENST00000460968
ENST00000484453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017048 Rho GTPase binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007266 Rho protein signal transduction
GO:0043086 negative regulation of catalytic activity
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034930
View Gene Order
ENSBTAG00000000490
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9BST9
TrEMBL
UniProt Splice Variant
Entrez Gene 6242
UniGene Hs.192854
RefSeq NM_001015055 NM_001015056 NM_033046
HUGO HGNC:10466
OMIM 602288
CCDS CCDS1941 CCDS33226 CCDS42699
HPRD
IMGT
EMBL AC005041 AF049227 AF290512 BC004558 BC017727
GenPept AAG01181 AAH04558 AAH17727 AAL16767
RNA Seq Atlas 6242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca