InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dpm2

Summary

InnateDB Gene

IDBG-160387.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dpm2

Gene Name

dolichol-phosphate (beta-D) mannosyltransferase 2

Synonyms

AW557993; R75484

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026810

Encoded Proteins

IDBP-160389

dolichol-phosphate (beta-D) mannosyltransferase 2

IDBP-538503

dolichol-phosphate (beta-D) mannosyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136908:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:32570858-32573579

Strand

Forward strand

Band

Transcripts

ENSMUST00000028151	ENSMUSP00000028151
ENSMUST00000140592	ENSMUSP00000124665
ENSMUST00000128039
ENSMUST00000150419

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0005515	protein binding
GO:0030234	enzyme regulator activity

Biological Process

GO:0006486	protein glycosylation
GO:0006506	GPI anchor biosynthetic process
GO:0009059	macromolecule biosynthetic process
GO:0019348	dolichol metabolic process
GO:0031647	regulation of protein stability
GO:0050790	regulation of catalytic activity
GO:0097502	mannosylation

Cellular Component

GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0033185	dolichol-phosphate-mannose synthase complex
GO:0048471	perinuclear region of cytoplasm