Homo sapiens Gene: DPM2
Summary
InnateDB Gene IDBG-87048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPM2
Gene Name dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Synonyms CDG1U;
Species Homo sapiens
Ensembl Gene ENSG00000136908
Encoded Proteins
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:127935099-127938484
Strand Reverse strand
Band q34.11
Transcripts
ENST00000314392 ENSP00000322181
ENST00000373110 ENSP00000362202
ENST00000495270
ENST00000470181
ENST00000473360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity
GO:0005515 protein binding
GO:0030234 enzyme regulator activity
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0009059 macromolecule biosynthetic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019348 dolichol metabolic process
GO:0031647 regulation of protein stability
GO:0035269 protein O-linked mannosylation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0050790 regulation of catalytic activity
GO:0097502 mannosylation
Cellular Component
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0033185 dolichol-phosphate-mannose synthase complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Post-translational modification: synthesis of GPI-anchored proteins pathway
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Synthesis of glycosylphosphatidylinositol (GPI) pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Synthesis of dolichyl-phosphate mannose pathway
KEGG
N-Glycan biosynthesis pathway
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.108973
RefSeq NM_003863
HUGO
OMIM
CCDS CCDS6886
HPRD 16028
IMGT
EMBL
GenPept
RNA Seq Atlas