Mus musculus Gene: Ankrd1
Summary
InnateDB Gene IDBG-160531.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ankrd1
Gene Name ankyrin repeat domain 1 (cardiac muscle)
Synonyms Alrp; CARP; Crap; MARP1;
Species Mus musculus
Ensembl Gene ENSMUSG00000024803
Encoded Proteins
ankyrin repeat domain 1 (cardiac muscle)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148677:
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:36111965-36119844
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000025718 ENSMUSP00000025718
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0031432 titin binding
GO:0042826 histone deacetylase binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010976 positive regulation of neuron projection development
GO:0035690 cellular response to drug
GO:0035914 skeletal muscle cell differentiation
GO:0035994 response to muscle stretch
GO:0043065 positive regulation of apoptotic process
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050714 positive regulation of protein secretion
GO:0055008 cardiac muscle tissue morphogenesis
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0071456 cellular response to hypoxia
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030016 myofibril
GO:0031674 I band
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
PPARA activates gene expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
PPARA activates gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9CR42
TrEMBL
UniProt Splice Variant
Entrez Gene 107765
UniGene Mm.10279
RefSeq NM_013468
OMIM
CCDS CCDS29771
HPRD
IMGT
MGI ID MGI:1097717
MGI Symbol Ankrd1
EMBL AF041847 AF041849 AK009655 AK009959 AK145944 AK146471 AK146627 AK146940 BC037138
GenPept AAB97080 AAC03533 AAH37138 BAB26419 BAB26611 BAE26773 BAE27197 BAE27316 BAE27549
RNA Seq Atlas 107765