InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ankrd1

Summary

InnateDB Protein

IDBP-160533.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ankrd1

Protein Name

ankyrin repeat domain 1 (cardiac muscle)

Synonyms

Alrp; CARP; Crap; MARP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025718

InnateDB Gene

IDBG-160531 (Ankrd1)

Protein Structure

UniProt Annotation

Function

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. {ECO:0000269PubMed:9043061}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, cardiac muscle. {ECO:0000269PubMed:9043061}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0031432	titin binding
GO:0042826	histone deacetylase binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0010976	positive regulation of neuron projection development
GO:0035690	cellular response to drug
GO:0035914	skeletal muscle cell differentiation
GO:0035994	response to muscle stretch
GO:0043065	positive regulation of apoptotic process
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050714	positive regulation of protein secretion
GO:0055008	cardiac muscle tissue morphogenesis
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071407	cellular response to organic cyclic compound
GO:0071456	cellular response to hypoxia
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2000279	negative regulation of DNA biosynthetic process