Mus musculus Gene: Fbxw11
Summary
InnateDB Gene IDBG-160575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxw11
Gene Name F-box and WD-40 domain protein 11
Synonyms 2310065A07Rik; AA536858; BTRC2; BTRCP2; Fbxw1b; HOS;
Species Mus musculus
Ensembl Gene ENSMUSG00000020271
Encoded Proteins
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 11
F-box and WD-40 domain protein 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072803:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:32642724-32746816
Strand Forward strand
Band A4
Transcripts
ENSMUST00000076383 ENSMUSP00000075721
ENSMUST00000093205 ENSMUSP00000090893
ENSMUST00000109366 ENSMUSP00000104991
ENSMUST00000137898
ENSMUST00000143290 ENSMUSP00000116834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006470 protein dephosphorylation
GO:0007049 cell cycle
GO:0016055 Wnt signaling pathway
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648 protein destabilization
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0042752 regulation of circadian rhythm
GO:0042753 positive regulation of circadian rhythm
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048511 rhythmic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G2/M Transition pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Cell Cycle pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Mitotic G2-G2/M phases pathway
Activation of NF-kappaB in B cells pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Adaptive Immune System pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Circadian rhythm pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
Prolactin pathway
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Mitotic G2-G2/M phases pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Circadian rhythm pathway
Shigellosis pathway
INOH
PID BIOCARTA
PID NCI
Presenilin action in Notch and Wnt signaling
Signaling events mediated by VEGFR1 and VEGFR2
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt Q5SRY7
TrEMBL Q922C7
UniProt Splice Variant
Entrez Gene 103583
UniGene Mm.28017 Mm.474118
RefSeq NM_001271347 XM_006514435 XM_006514436 NM_001271348 NM_001271349 NM_134015 XM_006514434 XM_006514433
OMIM
CCDS CCDS70157 CCDS36125 CCDS70158
HPRD
IMGT
MGI ID MGI:2144023
MGI Symbol Fbxw11
EMBL AK041532 AK149139 AK152181 AK160086 AK166226 AK168667 AL669844 AL669951 AY038079 BC008552 BC034261
GenPept AAH08552 AAH34261 AAK72095 BAC30975 BAE28749 BAE31012 BAE35617 BAE38644 BAE40519 CAI25519 CAI25520 CAI26097 CAI26098
RNA Seq Atlas 103583