InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GADD45B

Summary

InnateDB Gene

IDBG-16168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45B

Gene Name

growth arrest and DNA-damage-inducible, beta

Synonyms

GADD45BETA; MYD118

Species

Homo sapiens

Ensembl Gene

ENSG00000099860

Encoded Proteins

IDBP-16170

growth arrest and DNA-damage-inducible, beta

IDBP-764553

IDBP-766016

IDBP-764565

IDBP-761396

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:2476122-2478259

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000215631	ENSP00000215631
ENST00000587345	ENSP00000467490
ENST00000586759
ENST00000585359	ENSP00000466414
ENST00000587887	ENSP00000468620
ENST00000592937
ENST00000593043	ENSP00000468374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	15 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000186	activation of MAPKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1900745	positive regulation of p38MAPK cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000015312

View Gene Order

ENSBTAG00000025462

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04110

Cell cycle pathway

hsa04010

MAPK signaling pathway pathway

hsa04115

p53 signaling pathway pathway

INOH

PID NCI

il12_2pathway

IL12-mediated signaling events

Cross-References

SwissProt

TrEMBL

K7EPQ8 Q6IX74

UniProt Splice Variant

Entrez Gene

4616

UniGene

Hs.110571

RefSeq

NM_015675

HUGO

HGNC:4096

OMIM

604948

CCDS

CCDS32868

HPRD

05382

IMGT

EMBL

AC005624 AY615270 AY615271

GenPept

AAT38867 AAT38868

RNA Seq Atlas

4616