InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GADD45B

Summary

InnateDB Protein

IDBP-16170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45B

Protein Name

growth arrest and DNA-damage-inducible, beta

Synonyms

GADD45BETA; MYD118;

Species

Homo sapiens

Ensembl Protein

ENSP00000215631

InnateDB Gene

IDBG-16168 (GADD45B)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	15 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000186	activation of MAPKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1900745	positive regulation of p38MAPK cascade