InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tfam

Summary

InnateDB Gene

IDBG-161688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfam

Gene Name

transcription factor A, mitochondrial

Synonyms

AI661103; Hmgts; mtTFA; tsHMG

Species

Mus musculus

Ensembl Gene

ENSMUSG00000003923

Encoded Proteins

IDBP-161690

transcription factor A, mitochondrial

IDBP-270892

transcription factor A, mitochondrial

IDBP-401125

transcription factor A, mitochondrial

IDBP-537820

transcription factor A, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108064:
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer\'s and Parkinson\'s diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:71225464-71238280

Strand

Reverse strand

Band

B5.3

Transcripts

ENSMUST00000092430	ENSMUSP00000090086
ENSMUST00000105432	ENSMUSP00000101072
ENSMUST00000121685	ENSMUSP00000113581
ENSMUST00000145220
ENSMUST00000152505	ENSMUSP00000120871

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0031072	heat shock protein binding
GO:0044822	poly(A) RNA binding
GO:0070363	mitochondrial light strand promoter sense binding

Biological Process

GO:0006390	transcription from mitochondrial promoter
GO:0006391	transcription initiation from mitochondrial promoter
GO:0033108	mitochondrial respiratory chain complex assembly
GO:0045893	positive regulation of transcription, DNA-templated