InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfam

Summary

InnateDB Protein

IDBP-401125.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfam

Protein Name

transcription factor A, mitochondrial

Synonyms

AI661103; Hmgts; mtTFA; tsHMG;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113581

InnateDB Gene

IDBG-161688 (Tfam)

Protein Structure

UniProt Annotation

Function

Isoform Mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. Isoform Nuclear may also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis. {ECO:0000269PubMed:17581862, ECO:0000269PubMed:8673128, ECO:0000269PubMed:9500544}.

Subcellular Localization

Isoform Mitochondrial: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}.Isoform Nuclear: Nucleus.

Disease Associations

Tissue Specificity

The mitochondrial isoform is widely expressed while the nuclear isoform is testis-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008301	DNA binding, bending
GO:0031072	heat shock protein binding
GO:0070363	mitochondrial light strand promoter sense binding

Biological Process

GO:0006390	transcription from mitochondrial promoter
GO:0006391	transcription initiation from mitochondrial promoter
GO:0033108	mitochondrial respiratory chain complex assembly
GO:0045893	positive regulation of transcription, DNA-templated