InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbl

Summary

InnateDB Gene

IDBG-162300.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbl

Gene Name

fibrillarin

Synonyms

AL022665; FIB; FLRN; RNU3IP1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000046865

Encoded Proteins

IDBP-162302

fibrillarin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105202:
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8%% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:28169748-28179269

Strand

Forward strand

Band

Transcripts

ENSMUST00000042405

ENSMUSP00000037613

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding
GO:1990259	histone-glutamine methyltransferase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006364	rRNA processing
GO:0008033	tRNA processing
GO:0016074	snoRNA metabolic process
GO:1990258	histone glutamine methylation

Cellular Component

GO:0001652	granular component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105202

View Gene Order

ENSBTAG00000002579

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

P35550

TrEMBL

UniProt Splice Variant

Entrez Gene

14113

UniGene

RefSeq

NM_007991 XM_006543766

OMIM

CCDS

CCDS21036

HPRD

IMGT

MGI ID

MGI:95486

MGI Symbol

Fbl

EMBL

BC003813 BC092274 Z22593

GenPept

AAH03813 AAH92274 CAA80307

RNA Seq Atlas

102643269 14113