InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbl

Summary

InnateDB Protein

IDBP-162302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbl

Protein Name

fibrillarin

Synonyms

AL022665; FIB; FLRN; RNU3IP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037613

InnateDB Gene

IDBG-162300 (Fbl)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus. Note=Fibrillar region of the nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0030515	snoRNA binding
GO:0044822	poly(A) RNA binding
GO:1990259	histone-glutamine methyltransferase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006364	rRNA processing
GO:0008033	tRNA processing
GO:0016074	snoRNA metabolic process
GO:1990258	histone glutamine methylation

Cellular Component

GO:0001652	granular component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95486

InterPro

IPR000692 Fibrillarin
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF01269

PRINTS

PR00052

PIRSF

PIRSF006540

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35550

PhosphoSite

PhosphoSite-P35550

TrEMBL

UniProt Splice Variant

Entrez Gene

14113

UniGene

RefSeq

NP_032017

MGI ID

MGI Symbol

Fbl

OMIM

CCDS

CCDS21036

HPRD

IMGT

EMBL

BC003813 BC092274 Z22593

GenPept

AAH03813 AAH92274 CAA80307