Homo sapiens Gene: IFITM3
Summary
InnateDB Gene IDBG-16268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFITM3
Gene Name interferon induced transmembrane protein 3
Synonyms 1-8U; DSPA2b; IP15;
Species Homo sapiens
Ensembl Gene ENSG00000142089
Encoded Proteins
interferon induced transmembrane protein 3
interferon induced transmembrane protein 3
interferon induced transmembrane protein 3
interferon induced transmembrane protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IFITM3 is an antiviral restriction factor that mediates cellular resistance to influenza A H1N1 virus, West Nile virus, and Dengue virus.
IFITM3 is post-translationally regulated by S-palmitoylation on membrane-proximal cysteines, which controls its clustering in membrane compartments and its antiviral activity against influenza virus.
NRAV, a long noncoding RNA, modulates antiviral responses by negatively regulating the initial transcription of multiple critical interferon-stimulated genes, including IFITM3 and MX1, by affecting their histone modification.
Entrez Gene
Summary The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:319669-327537
Strand Reverse strand
Band p15.5
Transcripts
ENST00000399808 ENSP00000382707
ENST00000531688 ENSP00000473645
ENST00000526811 ENSP00000432108
ENST00000602735 ENSP00000473544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 7 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0009607 response to biotic stimulus
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0032897 negative regulation of viral transcription
GO:0034341 response to interferon-gamma
GO:0035455 response to interferon-alpha
GO:0035456 response to interferon-beta
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0046597 negative regulation of viral entry into host cell
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q01628
TrEMBL E9PS44
UniProt Splice Variant
Entrez Gene 10410
UniGene
RefSeq NM_021034
HUGO HGNC:5414
OMIM 605579
CCDS CCDS41585
HPRD
IMGT
EMBL AC136475 AK292173 BC006794 BC008417 BC022439 BC070243 BT006892 CH891444 JQ610571 JQ610572 JQ610573 JQ610574 JQ610575 JQ610576 JQ610577 JQ610578 JQ610579 JQ610580 JQ610581 JQ610582 JQ610583 JQ610585 JQ610586 JQ610587 JQ610588 JQ610589 JQ610590 JQ610591 JQ610592 JQ610593 JQ610594 JQ610595 JQ610596 JQ610597 JQ610598 JQ610599 JQ610600 JQ610601 JQ610602 JQ610603 JQ610604 JQ610605 JQ610606 JQ610607 JQ610608 JQ610609 JQ610610 JQ610611 JQ610613 JQ610614 JQ610615 JQ610616 JQ610617 JQ610618 JQ610620 JQ610621 X57352
GenPept AAH06794 AAH08417 AAH22439 AAH70243 AAP35538 AFF60305 AFF60306 AFF60307 AFF60308 AFF60309 AFF60310 AFF60311 AFF60312 AFF60313 AFF60314 AFF60315 AFF60316 AFF60317 AFF60319 AFF60320 AFF60321 AFF60322 AFF60323 AFF60324 AFF60325 AFF60326 AFF60327 AFF60328 AFF60329 AFF60330 AFF60331 AFF60332 AFF60333 AFF60334 AFF60335 AFF60336 AFF60337 AFF60338 AFF60339 AFF60340 AFF60341 AFF60342 AFF60343 AFF60344 AFF60345 AFF60347 AFF60348 AFF60349 AFF60350 AFF60351 AFF60352 AFF60354 AFF60355 BAF84862 CAA40626 EAW50866
RNA Seq Atlas 10410