InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IFITM3

Summary

InnateDB Gene

IDBG-16268.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFITM3

Gene Name

interferon induced transmembrane protein 3

Synonyms

1-8U; DSPA2b; IP15

Species

Homo sapiens

Ensembl Gene

ENSG00000142089

Encoded Proteins

IDBP-229735

interferon induced transmembrane protein 3

IDBP-812092

interferon induced transmembrane protein 3

IDBP-589924

interferon induced transmembrane protein 3

IDBP-812093

interferon induced transmembrane protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20064371

IFITM3 is an antiviral restriction factor that mediates cellular resistance to influenza A H1N1 virus, West Nile virus, and Dengue virus.

PMID 20601941

IFITM3 is post-translationally regulated by S-palmitoylation on membrane-proximal cysteines, which controls its clustering in membrane compartments and its antiviral activity against influenza virus.

PMID 25525793

NRAV, a long noncoding RNA, modulates antiviral responses by negatively regulating the initial transcription of multiple critical interferon-stimulated genes, including IFITM3 and MX1, by affecting their histone modification.

Entrez Gene

Summary

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:319669-327537

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000399808	ENSP00000382707
ENST00000531688	ENSP00000473645
ENST00000526811	ENSP00000432108
ENST00000602735	ENSP00000473544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	7 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0009607	response to biotic stimulus
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0032897	negative regulation of viral transcription
GO:0034341	response to interferon-gamma
GO:0035455	response to interferon-alpha
GO:0035456	response to interferon-beta
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_25162

Interferon alpha/beta signaling pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_25229

Interferon Signaling pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

10410

UniGene

RefSeq

NM_021034

HUGO

HGNC:5414

OMIM

605579

CCDS

CCDS41585

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas

10410