Version 5.4
Mus musculus Gene: Wwc1
Summary
InnateDB Gene IDBG-162865.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wwc1
Gene Name WW, C2 and coiled-coil domain containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000018849
Encoded Proteins
IDBP-162867
WW, C2 and coiled-coil domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113645:
The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:35838400-35980527
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000018993 ENSMUSP00000018993
ENSMUST00000131001
ENSMUST00000127086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0030674 protein binding, bridging
GO:0032947 protein complex scaffold
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016477 cell migration
GO:0035330 regulation of hippo signaling
GO:0035331 negative regulation of hippo signaling
GO:0043410 positive regulation of MAPK cascade
GO:0046621 negative regulation of organ growth
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0032587 ruffle membrane
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113645
View Gene Order
ENSBTAG00000013880
Not yet available
Pathways
NETPATH
REACTOME
REACT_196537
Signaling by Hippo pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118607
Signaling by Hippo pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.31267 Mm.397207
RefSeq NM_170779
OMIM
CCDS CCDS24545
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca