InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wwc1

Summary

InnateDB Protein

IDBP-162867.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wwc1

Protein Name

WW, C2 and coiled-coil domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018993

InnateDB Gene

IDBG-162865 (Wwc1)

Protein Structure

UniProt Annotation

Function

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade. {ECO:0000250, ECO:0000269PubMed:18190796}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18190796}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with PRKCZ in the perinuclear region. {ECO:0000250}.

Disease Associations

Tissue Specificity

Mammary epithelium. {ECO:0000269PubMed:18190796}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0030674	protein binding, bridging
GO:0032947	protein complex scaffold

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016477	cell migration
GO:0035330	regulation of hippo signaling
GO:0035331	negative regulation of hippo signaling
GO:0043410	positive regulation of MAPK cascade
GO:0046621	negative regulation of organ growth

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0032587	ruffle membrane
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm