Homo sapiens Gene: MNT
Summary
InnateDB Gene IDBG-16287.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MNT
Gene Name MNT, MAX dimerization protein
Synonyms bHLHd3; MAD6; MXD6; ROX;
Species Homo sapiens
Ensembl Gene ENSG00000070444
Encoded Proteins
MAX binding protein
MAX network transcriptional repressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:2384060-2401118
Strand Reverse strand
Band p13.3
Transcripts
ENST00000174618 ENSP00000174618
ENST00000571836
ENST00000573384
ENST00000575374
ENST00000572892
ENST00000571232
ENST00000575394 ENSP00000476269
ENST00000574559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007275 multicellular organismal development
GO:0007569 cell aging
GO:0008285 negative regulation of cell proliferation
GO:0051726 regulation of cell cycle
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619541 Hs.626579 Hs.632239
RefSeq NM_020310
HUGO
OMIM
CCDS CCDS11018
HPRD 04331
IMGT
EMBL
GenPept
RNA Seq Atlas