Homo sapiens Gene: LAMA3
Summary
InnateDB Gene IDBG-1631.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMA3
Gene Name laminin, alpha 3
Synonyms BM600; E170; lama3a; LAMNA; LOCS;
Species Homo sapiens
Ensembl Gene ENSG00000053747
Encoded Proteins
laminin, alpha 3
laminin, alpha 3
laminin, alpha 3
laminin, alpha 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:23689443-23955066
Strand Forward strand
Band q11.2
Transcripts
ENST00000313654 ENSP00000324532
ENST00000269217 ENSP00000269217
ENST00000399516 ENSP00000382432
ENST00000586751 ENSP00000464836
ENST00000585600 ENSP00000468316
ENST00000592442
ENST00000592519 ENSP00000467662
ENST00000587184 ENSP00000466557
ENST00000588004 ENSP00000468315
ENST00000591749
ENST00000588770
ENST00000588164 ENSP00000467473
ENST00000590104 ENSP00000466658
ENST00000586709
ENST00000616172 ENSP00000479087
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008544 epidermis development
GO:0022617 extracellular matrix disassembly
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030334 regulation of cell migration
GO:0031581 hemidesmosome assembly
GO:0034329 cell junction assembly
GO:0045995 regulation of embryonic development
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005606 laminin-1 complex
GO:0005610 laminin-5 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
REACTOME
Cell-Cell communication pathway
Extracellular matrix organization pathway
Cell junction organization pathway
Degradation of the extracellular matrix pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
Assembly of collagen fibrils and other multimeric structures pathway
Type I hemidesmosome assembly pathway
Collagen formation pathway
Anchoring fibril formation pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Toxoplasmosis pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
Beta1 integrin cell surface interactions
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Alpha6 beta4 integrin-ligand interactions
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436367 Hs.606148 Hs.667382 Hs.685087
RefSeq NM_000227 NM_001127717 NM_001127718 NM_198129
HUGO
OMIM
CCDS CCDS11880 CCDS42419 CCDS45838 CCDS59307
HPRD 02883
IMGT
EMBL
GenPept
RNA Seq Atlas