InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CAMK1

Summary

InnateDB Gene

IDBG-16330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAMK1

Gene Name

calcium/calmodulin-dependent protein kinase I

Synonyms

CAMKI

Species

Homo sapiens

Ensembl Gene

ENSG00000134072

Encoded Proteins

IDBP-16332

calcium/calmodulin-dependent protein kinase I

IDBP-235718

calcium/calmodulin-dependent protein kinase I

IDBP-361791

calcium/calmodulin-dependent protein kinase I

IDBP-361796

calcium/calmodulin-dependent protein kinase I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:9757342-9769992

Strand

Reverse strand

Band

p25.3

Transcripts

ENST00000256460	ENSP00000256460
ENST00000397277	ENSP00000380447
ENST00000421120	ENSP00000393238
ENST00000411972	ENSP00000404587
ENST00000496534
ENST00000482803

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004683	calmodulin-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006913	nucleocytoplasmic transport
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0010976	positive regulation of neuron projection development
GO:0032880	regulation of protein localization
GO:0043393	regulation of protein binding
GO:0046827	positive regulation of protein export from nucleus
GO:0051147	regulation of muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0051835	positive regulation of synapse structural plasticity
GO:0060999	positive regulation of dendritic spine development
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030272

View Gene Order

ENSBTAG00000007780

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_003656 XM_005265517

HUGO

OMIM

CCDS

CCDS2582

HPRD

05412

IMGT

EMBL

GenPept

RNA Seq Atlas