Mus musculus Gene: Il2rg
Summary
InnateDB Gene IDBG-163447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il2rg
Gene Name interleukin 2 receptor, gamma chain
Synonyms [g]c; CD132; gamma(c); gc;
Species Mus musculus
Ensembl Gene ENSMUSG00000031304
Encoded Proteins
interleukin 2 receptor, gamma chain
interleukin 2 receptor, gamma chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL2RG physically associates with JAK2, suggesting that regulation of JAK2 may be linked to IL2 induced signal transduction.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147168:
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:101264378-101268255
Strand Reverse strand
Band D
Transcripts
ENSMUST00000033664 ENSMUSP00000033664
ENSMUST00000135038 ENSMUSP00000123318
ENSMUST00000145074
ENSMUST00000127538
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
GO:0019976 interleukin-2 binding
Biological Process
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0045579 positive regulation of B cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
INOH
IL-4 signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL2 pathway
IL4 pathway
IL-7 pathway
IL9 pathway
REACTOME
Interleukin-3, 5 and GM-CSF signaling pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPVI-mediated activation cascade pathway
Interleukin-2 signaling pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
Interleukin-7 signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Interleukin-7 signaling pathway
Hemostasis pathway
Immune System pathway
Interleukin receptor SHC signaling pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
GPCR downstream signaling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by Interleukins pathway
G beta:gamma signalling through PI3Kgamma pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Jak-STAT signaling pathway pathway
Primary immunodeficiency pathway
INOH
IL-7 signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
PID BIOCARTA
Il 2 signaling pathway [Biocarta view]
Il-2 receptor beta chain in t cell activation [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Il-7 signal transduction [Biocarta view]
PID NCI
IL2-mediated signaling events
Downstream signaling in na´ve CD8+ T cells
IL12-mediated signaling events
IL4-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.2923 Mm.404153
RefSeq NM_013563
OMIM
CCDS CCDS30312
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas