Mus musculus Gene: Abcg1
Summary
InnateDB Gene IDBG-163644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abcg1
Gene Name ATP-binding cassette, sub-family G (WHITE), member 1
Synonyms Abc8; AW413978; White;
Species Mus musculus
Ensembl Gene ENSMUSG00000024030
Encoded Proteins
ATP-binding cassette, sub-family G (WHITE), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Abcg1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defense response driven predominantly by hematopoietic cells.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ABCG1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defence response driven predominantly by hematopoietic cells.
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:31057698-31115777
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000024829 ENSMUSP00000024829
ENSMUST00000139013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0017127 cholesterol transporter activity
GO:0019534 toxin transporter activity
GO:0034041 sterol-transporting ATPase activity
GO:0034437 glycoprotein transporter activity
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
GO:0008203 cholesterol metabolic process
GO:0010033 response to organic substance
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010872 regulation of cholesterol esterification
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0030301 cholesterol transport
GO:0032367 intracellular cholesterol transport
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0033993 response to lipid
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034436 glycoprotein transport
GO:0042632 cholesterol homeostasis
GO:0042987 amyloid precursor protein catabolic process
GO:0043691 reverse cholesterol transport
GO:0045087 innate immune response (InnateDB)
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0055091 phospholipid homeostasis
GO:0055099 response to high density lipoprotein particle stimulus
GO:1901998 toxin transport
Cellular Component
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
HDL-mediated lipid transport pathway
Metabolism pathway
ABCA transporters in lipid homeostasis pathway
Metabolism of lipids and lipoproteins pathway
Lipid digestion, mobilization, and transport pathway
Lipoprotein metabolism pathway
Transmembrane transport of small molecules pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Metabolism of lipids and lipoproteins pathway
ABCA transporters in lipid homeostasis pathway
ABC-family proteins mediated transport pathway
HDL-mediated lipid transport pathway
Lipoprotein metabolism pathway
Metabolism pathway
Lipid digestion, mobilization, and transport pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q64343
TrEMBL Q0VDW9
UniProt Splice Variant
Entrez Gene 11307
UniGene Mm.15691
RefSeq NM_009593
OMIM
CCDS CCDS28602
HPRD
IMGT
MGI ID MGI:107704
MGI Symbol Abcg1
EMBL AF323659 BC119471 CH466640 U34920 Z48745
GenPept AAB47738 AAI19472 AAK27442 CAA88636 EDL40378
RNA Seq Atlas 11307