InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.29337

Summary

InnateDB Gene

IDBG-639382.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.29337

Gene Name

ATP-binding cassette sub-family G member 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021272

Encoded Proteins

IDBP-691542

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 20395559

[Homo sapiens] ABCG1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defence response driven predominantly by hematopoietic cells.

PMID 20395559

[Mus musculus] Abcg1 regulates innate immunity in a tissue-selective manner and Abcg1(-/-) mice have an enhanced pulmonary host defense response driven predominantly by hematopoietic cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160179:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:143990494-144053318

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028342

ENSBTAP00000028342

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005548	phospholipid transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0017127	cholesterol transporter activity
GO:0019534	toxin transporter activity
GO:0034041	sterol-transporting ATPase activity
GO:0034437	glycoprotein transporter activity
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006810	transport
GO:0008203	cholesterol metabolic process
GO:0010033	response to organic substance
GO:0010872	regulation of cholesterol esterification
GO:0010875	positive regulation of cholesterol efflux
GO:0010888	negative regulation of lipid storage
GO:0030301	cholesterol transport
GO:0032367	intracellular cholesterol transport
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0033993	response to lipid
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034436	glycoprotein transport
GO:0042632	cholesterol homeostasis
GO:0042987	amyloid precursor protein catabolic process
GO:0043691	reverse cholesterol transport
GO:0045542	positive regulation of cholesterol biosynthetic process
GO:0055091	phospholipid homeostasis
GO:0055099	response to high density lipoprotein particle stimulus
GO:1901998	toxin transport

Cellular Component

GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0055037	recycling endosome