Version 5.4
Mus musculus Gene: Mif
Summary
InnateDB Gene IDBG-163956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mif
Gene Name macrophage migration inhibitory factor
Synonyms GIF; Glif
Species Mus musculus
Ensembl Gene ENSMUSG00000033307
Encoded Proteins
IDBP-163958
macrophage migration inhibitory factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17435771
Gm16379 (Mif) is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to Cxcr2 and Cxcr4.
InnateDB Annotation from Orthologs
Summary
PMID 17435771
[Homo sapiens] MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000240972:
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75859353-75860250
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000038169 ENSMUSP00000041149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004167 dopachrome isomerase activity
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005515 protein binding
GO:0042056 chemoattractant activity
GO:0050178 phenylpyruvate tautomerase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0001934 positive regulation of protein phosphorylation
GO:0002821 positive regulation of adaptive immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0007569 cell aging
GO:0008283 cell proliferation
GO:0010629 negative regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0019752 carboxylic acid metabolic process
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030890 positive regulation of B cell proliferation
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032269 negative regulation of cellular protein metabolic process
GO:0033033 negative regulation of myeloid cell apoptotic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042127 regulation of cell proliferation
GO:0042327 positive regulation of phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 innate immune response (InnateDB)
GO:0048146 positive regulation of fibroblast proliferation
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0061078 positive regulation of prostaglandin secretion involved in immune response
GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response
GO:0070207 protein homotrimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071157 negative regulation of cell cycle arrest
GO:0090238 positive regulation of arachidonic acid secretion
GO:0090344 negative regulation of cell aging
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000240972
View Gene Order
ENSBTAG00000007375
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00350
Tyrosine metabolism pathway
mmu00360
Phenylalanine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00360
Phenylalanine metabolism pathway
hsa00350
Tyrosine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P34884
TrEMBL Q545F0
UniProt Splice Variant
Entrez Gene 17319
UniGene
RefSeq NM_010798
OMIM
CCDS CCDS23934
HPRD
IMGT
MGI ID MGI:96982
MGI Symbol Mif
EMBL AK008939 AK010691 AK013328 AK152211 BC024895 BC086928 BC100605 CH466553 L07607 L10613 L39357 U19825 U20156 Z23048
GenPept AAA37111 AAA37693 AAA74321 AAA91637 AAA91638 AAH24895 AAH86928 AAI00606 BAB25980 BAB27123 BAB28792 BAE31039 CAA80583 EDL31879
RNA Seq Atlas 17319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca