|Homo sapiens Gene: MIF|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||macrophage migration inhibitory factor (glycosylation-inhibiting factor)|
|Synonyms||GIF; GLIF; MMIF;|
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
|Useful resources||Stemformatics EHFPI ImmGen|
MIF is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to CXCR2 and CXCR4. (Demonstrated in murine model)
|InnateDB Annotation from Orthologs|
[Mus musculus] Gm16379 (Mif) is a chemokine-like inflammatory mediator that triggers leukocyte recruitment by binding to Cxcr2 and Cxcr4.
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 22:23894004-23895227|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Tyrosine metabolism pathway
Phenylalanine metabolism pathway
|UniProt Splice Variant|
|RNA Seq Atlas|