Version 5.4
Mus musculus Gene: Cryab
Summary
InnateDB Gene IDBG-164070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cryab
Gene Name crystallin, alpha B
Synonyms Crya-2; Crya2; HspB5; P23
Species Mus musculus
Ensembl Gene ENSMUSG00000032060
Encoded Proteins
IDBP-164072
crystallin, alpha B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23242137
CRYAB is a suppressor of neuroinflammation, and the suppression is mediated by DRD2 in astrocytes.
Entrez Gene
Summary This gene encodes a member of the small heat-shock protein (HSP20) family. The encoded protein is a molecular chaperone that protects proteins against thermal denaturation and other stresses. This protein is a component of the eye lens, regulates lens differentiation and functions as a refractive element in the lens. This protein is a negative regulator of inflammation, has anti-apoptotic properties and also plays a role in the formation of muscular tissue. Mice lacking this gene exhibit worse experimental autoimmune encephalomyelitis and inflammation of the central nervous system compared to the wild type. In mouse models, this gene has a critical role in alleviating the pathology of the neurodegenerative Alexander disease. Mutations in the human gene are associated with myofibrillar myopathy 2, fatal infantile hypertonic myofibrillar myopathy, multiple types of cataract and dilated cardiomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:50752758-50756633
Strand Forward strand
Band A5.3
Transcripts
ENSMUST00000034562 ENSMUSP00000034562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0008092 cytoskeletal protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0002088 lens development in camera-type eye
GO:0006006 glucose metabolic process
GO:0006457 protein folding
GO:0007021 tubulin complex assembly
GO:0007517 muscle organ development
GO:0007568 aging
GO:0010629 negative regulation of gene expression
GO:0010941 regulation of cell death
GO:0030308 negative regulation of cell growth
GO:0031109 microtubule polymerization or depolymerization
GO:0032355 response to estradiol
GO:0032387 negative regulation of intracellular transport
GO:0042542 response to hydrogen peroxide
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051260 protein homooligomerization
GO:0051403 stress-activated MAPK cascade
GO:0060561 apoptotic process involved in morphogenesis
GO:0071480 cellular response to gamma radiation
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0015630 microtubule cytoskeleton
GO:0030018 Z disc
GO:0031674 I band
GO:0032432 actin filament bundle
GO:0043292 contractile fiber
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000109846
View Gene Order
ENSBTAG00000000434
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P23927
TrEMBL Q52L78
UniProt Splice Variant
Entrez Gene 12955
UniGene Mm.396762
RefSeq NM_001289782 NM_001289784 NM_009964 XM_006509970 XM_006509971 XM_006509972
OMIM
CCDS CCDS23172
HPRD
IMGT
MGI ID MGI:88516
MGI Symbol Cryab
EMBL AK146556 AK168999 BC010768 BC094033 CH466522 CT010341 M25770 M63170 M73741
GenPept AAA37133 AAA37472 AAA67045 AAH10768 AAH94033 BAE27257 BAE40798 CAJ18549 EDL25757 EDL25758 EDL25759
RNA Seq Atlas 12955

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca