InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cryab

Summary

InnateDB Protein

IDBP-164072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cryab

Protein Name

crystallin, alpha B

Synonyms

Crya-2; Crya2; HspB5; P23;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034562

InnateDB Gene

IDBG-164070 (Cryab)

Protein Structure

UniProt Annotation

Function

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Lens as well as other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0002088	lens development in camera-type eye
GO:0006006	glucose metabolic process
GO:0006457	protein folding
GO:0007021	tubulin complex assembly
GO:0007517	muscle organ development
GO:0007568	aging
GO:0010629	negative regulation of gene expression
GO:0010941	regulation of cell death
GO:0030308	negative regulation of cell growth
GO:0031109	microtubule polymerization or depolymerization
GO:0032355	response to estradiol
GO:0032387	negative regulation of intracellular transport
GO:0042542	response to hydrogen peroxide
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051260	protein homooligomerization
GO:0051403	stress-activated MAPK cascade
GO:0060561	apoptotic process involved in morphogenesis
GO:0071480	cellular response to gamma radiation
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0015630	microtubule cytoskeleton
GO:0030018	Z disc
GO:0031674	I band
GO:0032432	actin filament bundle
GO:0043292	contractile fiber
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:88516

InterPro

IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR003090 Alpha-crystallin, N-terminal
IPR008978 HSP20-like chaperone

PFAM

PF00011
PF00525

PRINTS

PR00299

PIRSF

PIRSF036514

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt