Version 5.4
Mus musculus Gene: Rnf31
Summary
InnateDB Gene IDBG-164239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf31
Gene Name ring finger protein 31
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000047098
Encoded Proteins
IDBP-164241
ring finger protein 31
IDBP-533358
ring finger protein 31
IDBP-536363
ring finger protein 31
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19136968
[Homo sapiens] RNF31 complexes with RBCK1 (LUBAC) and is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of IKBKG.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092098:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:55591708-55603693
Strand Forward strand
Band C3
Transcripts
ENSMUST00000019443 ENSMUSP00000019443
ENSMUST00000137296 ENSMUSP00000122955
ENSMUST00000140178 ENSMUSP00000118215
ENSMUST00000126544
ENSMUST00000133903
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0016567 protein ubiquitination
GO:0023035 CD40 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060546 negative regulation of necroptotic process
GO:0097039 protein linear polyubiquitination
Cellular Component
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0071797 LUBAC complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092098
View Gene Order
ENSBTAG00000005815
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_194346 XM_006519062
OMIM
CCDS CCDS27118
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca