Version 5.4
Mus musculus Gene: Rab14
Summary
InnateDB Gene IDBG-164259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rab14
Gene Name RAB14, member RAS oncogene family
Synonyms 0610030G24Rik; 2810475J17Rik; A830021G03Rik; AI314285; AI649155; D030017L14Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000026878
Encoded Proteins
IDBP-164261
RAB14, member RAS oncogene family
IDBP-254736
RAB14, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119396:
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:35180205-35201120
Strand Reverse strand
Band B
Transcripts
ENSMUST00000028238 ENSMUSP00000028238
ENSMUST00000113025 ENSMUSP00000108648
ENSMUST00000137709
ENSMUST00000142015
ENSMUST00000155483
ENSMUST00000148543
ENSMUST00000155359
ENSMUST00000126224
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009790 embryo development
GO:0015031 protein transport
GO:0032456 endocytic recycling
GO:0032880 regulation of protein localization
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045335 phagocytic vesicle
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000119396
View Gene Order
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000017803
Not yet available
Ortholuge
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q91V41
TrEMBL A2AL34 Q50HX4
UniProt Splice Variant
Entrez Gene 68365
UniGene Mm.198264
RefSeq NM_026697
OMIM
CCDS CCDS15959
HPRD
IMGT
MGI ID MGI:1915615
MGI Symbol Rab14
EMBL AB232609 AJ968955 AK002704 AK133963 AK160859 AK165812 AK168551 AK168867 AK169396 AL773523 BC009085 BC025139 BC056648 CH466542
GenPept AAH09085 AAH25139 AAH56648 BAB22298 BAE21957 BAE36051 BAE38391 BAE40426 BAE40686 BAE41143 BAF02871 CAI92125 EDL08645
RNA Seq Atlas 68365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca