InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab14

Summary

InnateDB Gene

IDBG-164259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab14

Gene Name

RAB14, member RAS oncogene family

Synonyms

0610030G24Rik; 2810475J17Rik; A830021G03Rik; AI314285; AI649155; D030017L14Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026878

Encoded Proteins

IDBP-164261

RAB14, member RAS oncogene family

IDBP-254736

RAB14, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119396:
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:35180205-35201120

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028238	ENSMUSP00000028238
ENSMUST00000113025	ENSMUSP00000108648
ENSMUST00000137709
ENSMUST00000142015
ENSMUST00000155483
ENSMUST00000148543
ENSMUST00000155359
ENSMUST00000126224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006895	Golgi to endosome transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009790	embryo development
GO:0015031	protein transport
GO:0032456	endocytic recycling
GO:0032880	regulation of protein localization

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0045335	phagocytic vesicle
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000119396

View Gene Order

ENSBTAG00000017803

Not yet available

Pathways

NETPATH

REACTOME

REACT_209837

Membrane Trafficking pathway

REACT_199054

Translocation of GLUT4 to the plasma membrane pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.198264

RefSeq

NM_026697

OMIM

CCDS

CCDS15959

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas