Version 5.4
Homo sapiens Gene: RAB14
Summary
InnateDB Gene IDBG-83359.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB14
Gene Name RAB14, member RAS oncogene family
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119396
Encoded Proteins
IDBP-83361
RAB14, member RAS oncogene family
IDBP-379409
RAB14, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:121178137-121223014
Strand Reverse strand
Band q33.2
Transcripts
ENST00000373840 ENSP00000362946
ENST00000451303 ENSP00000400107
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009790 embryo development
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032456 endocytic recycling
GO:0032880 regulation of protein localization
GO:0046907 intracellular transport
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005791 rough endoplasmic reticulum
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0043231 intracellular membrane-bounded organelle
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026878
View Gene Order
ENSBTAG00000017803
Not yet available
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P61106
TrEMBL A0A024R845 X6RFL8
UniProt Splice Variant
Entrez Gene 51552
UniGene Hs.371563 Hs.621699
RefSeq NM_016322
HUGO HGNC:16524
OMIM 612673
CCDS CCDS6827
HPRD 06693
IMGT
EMBL AF112206 AF152463 AF203689 AF498949 AK023524 AK090889 AL137068 AL162081 AY553875 BC006081 CH471090 CR457394
GenPept AAF00150 AAF17194 AAF19400 AAH06081 AAM21097 AAS64573 BAB14598 BAG52243 CAB82414 CAD20124 CAG33675 CAI12361 EAW87487 EAW87488
RNA Seq Atlas 51552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca