InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gsn

Summary

InnateDB Gene

IDBG-164316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsn

Gene Name

gelsolin

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026879

Encoded Proteins

IDBP-164318

gelsolin

IDBP-537984

gelsolin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148180:
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:35279663-35307892

Strand

Forward strand

Band

Transcripts

ENSMUST00000028239	ENSMUSP00000028239
ENSMUST00000142324	ENSMUSP00000118120
ENSMUST00000124323
ENSMUST00000139867

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0007568	aging
GO:0008154	actin polymerization or depolymerization
GO:0014003	oligodendrocyte development
GO:0016192	vesicle-mediated transport
GO:0030041	actin filament polymerization
GO:0030155	regulation of cell adhesion
GO:0042060	wound healing
GO:0042246	tissue regeneration
GO:0045471	response to ethanol
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051014	actin filament severing
GO:0051593	response to folic acid
GO:0051693	actin filament capping
GO:0060271	cilium morphogenesis
GO:0071276	cellular response to cadmium ion

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle