Version 5.4
Homo sapiens Gene: GSN
Summary
InnateDB Gene IDBG-83407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSN
Gene Name gelsolin
Synonyms ADF; AGEL
Species Homo sapiens
Ensembl Gene ENSG00000148180
Encoded Proteins
IDBP-83409
gelsolin
IDBP-83411
gelsolin
IDBP-83413
gelsolin
IDBP-83415
gelsolin
IDBP-83417
gelsolin
IDBP-83419
gelsolin
IDBP-241741
gelsolin
IDBP-379490
gelsolin
IDBP-379493
gelsolin
IDBP-379496
gelsolin
IDBP-379497
gelsolin
IDBP-379498
gelsolin
IDBP-595468
gelsolin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:121207794-121332843
Strand Forward strand
Band q33.2
Transcripts
ENST00000341272 ENSP00000340888
ENST00000373823 ENSP00000362929
ENST00000373818 ENSP00000362924
ENST00000373808 ENSP00000362914
ENST00000373807 ENSP00000362913
ENST00000373806 ENSP00000362912
ENST00000373805
ENST00000394353 ENSP00000377882
ENST00000432226 ENSP00000404226
ENST00000449773 ENSP00000410657
ENST00000412819 ENSP00000416586
ENST00000449733 ENSP00000409358
ENST00000436847 ENSP00000411293
ENST00000477863
ENST00000483960
ENST00000475428
ENST00000477104
ENST00000485767
ENST00000477553
ENST00000545652 ENSP00000445823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007568 aging
GO:0008154 actin polymerization or depolymerization
GO:0014003 oligodendrocyte development
GO:0016192 vesicle-mediated transport
GO:0030041 actin filament polymerization
GO:0030155 regulation of cell adhesion
GO:0042060 wound healing
GO:0042246 tissue regeneration
GO:0045471 response to ethanol
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051014 actin filament severing
GO:0051016 barbed-end actin filament capping
GO:0051593 response to folic acid
GO:0060271 cilium morphogenesis
GO:0071276 cellular response to cadmium ion
Cellular Component
GO:0001726 ruffle
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026879
View Gene Order
ENSBTAG00000019915
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_4
EGFR1 pathway
REACTOME
REACT_13541
Caspase-mediated cleavage of cytoskeletal proteins pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_75925
Amyloids pathway
REACT_578
Apoptosis pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
caspase_pathway
Caspase Cascade in Apoptosis
ar_pathway
Coregulation of Androgen receptor activity
ncadherinpathway
N-cadherin signaling events
avb3_opn_pathway
Osteopontin-mediated events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000177 NM_001127662 NM_001127663 NM_001127664 NM_001127665 NM_001127666 NM_001127667 NM_001258029 NM_001258030 NM_198252 XM_005251940 XM_005251943 XM_005251944 XM_005251945 XM_006717075 XM_006717076 XM_006717077 XM_006717078 XM_006717079
HUGO
OMIM
CCDS CCDS48011 CCDS65118 CCDS6828 CCDS6829 CCDS75890 CCDS75891
HPRD 00674
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca