InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adar

Summary

InnateDB Gene

IDBG-164791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adar

Gene Name

adenosine deaminase, RNA-specific

Synonyms

Adar1; Adar1p110; Adar1p150; AV242451; mZaADAR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027951

Encoded Proteins

IDBP-164793

adenosine deaminase, RNA-specific

IDBP-164795

adenosine deaminase, RNA-specific

IDBP-266737

adenosine deaminase, RNA-specific

IDBP-401066

adenosine deaminase, RNA-specific

IDBP-401064

adenosine deaminase, RNA-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21809195

Adar destabalizes RNA structure by the deamination of adenosine to inosine, and therefore is able to disrupt replication of dsRNA viruses in the host.

PMID 26335850

Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.

InnateDB Annotation from Orthologs

Summary

PMID 21809195

[Homo sapiens] ADAR destabalizes RNA structure by the deamination of adenosine to inosine, and therefore is able to disrupt replication of dsRNA viruses in the host.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160710:
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:89715022-89753446

Strand

Forward strand

Band

Transcripts

ENSMUST00000098924	ENSMUSP00000096525
ENSMUST00000029563	ENSMUSP00000029563
ENSMUST00000107405	ENSMUSP00000103028
ENSMUST00000121094	ENSMUSP00000112969
ENSMUST00000118341	ENSMUSP00000113453
ENSMUST00000123691
ENSMUST00000150637
ENSMUST00000131030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003692	left-handed Z-DNA binding
GO:0003723	RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006382	adenosine to inosine editing
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006606	protein import into nucleus
GO:0006611	protein export from nucleus
GO:0009615	response to virus
GO:0016553	base conversion or substitution editing
GO:0031047	gene silencing by RNA
GO:0035455	response to interferon-alpha
GO:0043066	negative regulation of apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus