InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADAR

Summary

InnateDB Gene

IDBG-102968.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAR

Gene Name

adenosine deaminase, RNA-specific

Synonyms

ADAR1; AGS6; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; P136

Species

Homo sapiens

Ensembl Gene

ENSG00000160710

Encoded Proteins

IDBP-102970

adenosine deaminase, RNA-specific

IDBP-102972

adenosine deaminase, RNA-specific

IDBP-592266

adenosine deaminase, RNA-specific

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21809195

ADAR destabalizes RNA structure by the deamination of adenosine to inosine, and therefore is able to disrupt replication of dsRNA viruses in the host.

InnateDB Annotation from Orthologs

Summary

PMID 21809195

[Mus musculus] Adar destabalizes RNA structure by the deamination of adenosine to inosine, and therefore is able to disrupt replication of dsRNA viruses in the host.

PMID 26335850

[Mus musculus] Transcriptional activation of Adar by IFN occurs in the absence of Stat1 by a non-canonical Stat2-dependent pathway.

Entrez Gene

Summary

This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:154582062-154627999

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000368474	ENSP00000357459
ENST00000368471	ENSP00000357456
ENST00000492630
ENST00000463920
ENST00000494866
ENST00000471068
ENST00000529168	ENSP00000431794
ENST00000530954
ENST00000534279
ENST00000526905

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	37 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006382	adenosine to inosine editing
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006606	protein import into nucleus
GO:0006611	protein export from nucleus
GO:0009615	response to virus
GO:0010467	gene expression
GO:0016553	base conversion or substitution editing
GO:0016556	mRNA modification
GO:0019221	cytokine-mediated signaling pathway
GO:0031047	gene silencing by RNA
GO:0035455	response to interferon-alpha
GO:0043066	negative regulation of apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0051607	defense response to virus
GO:0060337	type I interferon signaling pathway