Version 5.4
Mus musculus Gene: Inadl
Summary
InnateDB Gene IDBG-165090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Inadl
Gene Name InaD-like (Drosophila)
Synonyms Cipp; Patj
Species Mus musculus
Ensembl Gene ENSMUSG00000061859
Encoded Proteins
IDBP-165092
InaD-like (Drosophila)
IDBP-165096
InaD-like (Drosophila)
IDBP-165098
InaD-like (Drosophila)
IDBP-267494
InaD-like (Drosophila)
IDBP-267496
InaD-like (Drosophila)
IDBP-267500
InaD-like (Drosophila)
IDBP-267502
InaD-like (Drosophila)
IDBP-536946
InaD-like (Drosophila)
IDBP-536993
InaD-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multivalent PDZ domain protein, which is expressed exclusively in brain and kidney. This protein selectively interacts with inward rectifier K+ (Kir) family members, N-methyl-D-aspartate receptor subunits, neurexins and neuroligins, as well as cell surface molecules enriched in synaptic membranes. Thus, this protein may serve as a scaffold that brings structurally diverse but functionally connected proteins into close proximity at the synapse. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:98395785-98719603
Strand Forward strand
Band C6
Transcripts
ENSMUST00000041284 ENSMUSP00000049176
ENSMUST00000030290 ENSMUSP00000030290
ENSMUST00000102792 ENSMUSP00000099854
ENSMUST00000107034 ENSMUSP00000102649
ENSMUST00000107033 ENSMUSP00000102648
ENSMUST00000107030 ENSMUSP00000102645
ENSMUST00000107029 ENSMUSP00000102644
ENSMUST00000141796
ENSMUST00000136675
ENSMUST00000141965
ENSMUST00000142103 ENSMUSP00000116021
ENSMUST00000135606
ENSMUST00000134901 ENSMUSP00000115936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005923 tight junction
GO:0016324 apical plasma membrane
GO:0043234 protein complex
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132849
View Gene Order
ENSBTAG00000021975
Not yet available
Pathways
NETPATH
REACTOME
REACT_248094
Cell-cell junction organization pathway
REACT_241978
Cell junction organization pathway
REACT_236746
Tight junction interactions pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04530
Tight junction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt Q63ZW7
TrEMBL A2ADL9 A2ADS6 A2ADS8 A2ADT1
UniProt Splice Variant
Entrez Gene 12695
UniGene Mm.474620 Mm.90218
RefSeq NM_001005787 NM_007704 NM_172696 XM_006502699 XM_006502700 XM_006502701 XM_006502702 XM_006502703 XM_006502704 XM_006502707
OMIM
CCDS CCDS18375 CCDS18376 CCDS18377
HPRD
IMGT
MGI ID MGI:1277960
MGI Symbol Inadl
EMBL AF060539 AK077268 AL627124 AL670941 AL671229 BC037607 BC050846 BC057124 BC062194 BC082787 BC141404
GenPept AAC40148 AAH37607 AAH50846 AAH57124 AAH62194 AAH82787 AAI41405 BAC36720 CAM27361
RNA Seq Atlas 12695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca