Version 5.4
Homo sapiens Gene: INADL
Summary
InnateDB Gene IDBG-99328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INADL
Gene Name InaD-like (Drosophila)
Synonyms Cipp; hINADL; InaD-like; PATJ
Species Homo sapiens
Ensembl Gene ENSG00000132849
Encoded Proteins
IDBP-99334
InaD-like (Drosophila)
IDBP-99336
InaD-like (Drosophila)
IDBP-99338
InaD-like (Drosophila)
IDBP-590409
InaD-like (Drosophila)
IDBP-806991
InaD-like (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:61742477-62163920
Strand Forward strand
Band p31.3
Transcripts
ENST00000307297 ENSP00000307496
ENST00000316485 ENSP00000326199
ENST00000371158 ENSP00000360200
ENST00000484562
ENST00000459752
ENST00000484937 ENSP00000433669
ENST00000488913
ENST00000493967
ENST00000494842
ENST00000490547
ENST00000465798
ENST00000472512
ENST00000613764 ENSP00000479041
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 49 [view]
Protein-Protein 47 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0034329 cell junction assembly
GO:0035556 intracellular signal transduction
GO:0045216 cell-cell junction organization
GO:0070830 tight junction assembly
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016324 apical plasma membrane
GO:0043234 protein complex
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061859
View Gene Order
ENSBTAG00000021975
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04530
Tight junction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478125
RefSeq NM_176877 XM_005270341 XM_005270343 XM_005270345 XM_005270347 XM_006710275 XM_006710276 XM_006710277 XM_006710278
HUGO
OMIM
CCDS CCDS617
HPRD 04434
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca